Duloxetine vs pregabalin

Duloxetine is an SNRI that inhibits reuptake of Serotonin and Norepinephrine from Synaptic clefts in Brain and Spinal Cord .Duloxetine has received its FDA approval for management of NeP in 1. Chronic Musculoskeletal pain like • Chronic Low Back pain and • Chronic Osteoarthritis pain with Neuropathic component 2. Peripheral Diabetic NeP According FDA approval for both Duloxetine and Pregabalin , Duloxetine has no abusepotential or dependence unlike Gabapentinoids Abuse potential of Gabapentinoids is due to increase extracellular level of GABA (Gamma Amino Butyric acid) ,inhibitory neurotransmitter in BrainIncreased level of GABA in Brain leads to Feeling high and Euphoria which experienced with Gabapentinoids at treatment initiation and with high doses The Increase of GABA related to use of Gabapentinoids is the main cause for Physical and Psychological dependence and abuse potential Duloxetine has no effect on GABA and so it has no abuse potential Duloxeprin the most effective and most safe treatment for NeP.